Search on:
KININOGEN, HIGH-MOLECULAR-WEIGHT
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Kininogen, High-Molecular-Weight
Descriptor
Spanish
:
Quininógeno de Alto Peso Molecular
Descriptor
Portuguese
:
Cininogênio de Alto Peso Molecular
Synonyms
English
:
High-Molecular-Weight Kininogen
Tree Number:
D12.644.276.812.654.350
D12.776.124.125.635.480
D12.776.467.812.654.350
D12.776.811.420.350
D23.119.630.480
D23.469.050.375.425.350
D23.529.812.654.350
Definition
English
:
A
plasma
protein,
molecular weight
of 110 kD, that normally exists in
plasma
in a 1:1 complex with
PREKALLIKREIN
. HMWK is split by
plasma kallikrein
to produce
BRADYKININ
. The complex is a cofactor in the activation of coagulation
factor XII
. The product of this reaction, XIIa, in turn activates
prekallikrein
to
KALLIKREINS
. (From Stedman, 26th ed)
Indexing Annotation
English
:
DF: HMWK
History Note
English
:
98; use KININOGENS 1989-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33486
Unique Identifier:
D019679
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS